Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts.

@article{Kalscheuer2014XenograftTA,
  title={Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts.},
  author={Hannes Kalscheuer and Takashi Onoe and Alexander Dahmani and Hao-Wei Li and Markus A. H{\"o}lzl and Kazuhiko Yamada and Megan Sykes},
  journal={Journal of immunology},
  year={2014},
  volume={192 7},
  pages={3442-50}
}
Transplantation of xenogeneic thymus tissue allows xenograft tolerance induction in the highly disparate pig-to-mouse model. Fetal swine thymus (SW THY) can support the generation of a diverse human T cell repertoire that is tolerant of the pig in vitro. We demonstrate that SW THY generates all human T cell subsets, including regulatory T cells (Tregs), in similar numbers as fetal human thymus (HU THY) grafts in immunodeficient mice receiving the same human CD34(+) cells. Peripheral T cells are… CONTINUE READING
5 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-5 of 5 extracted citations

Similar Papers

Loading similar papers…