Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knockout mice.

@article{Yamashita2007XenogenicMI,
  title={Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knockout mice.},
  author={T. Yamashita and S. Kawashima and T. Hirase and M. Shinohara and Tomofumi Takaya and Naoto Sasaki and Masafumi Takeda and Hideto Tawa and N. Inoue and K. Hirata and M. Yokoyama},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={293 3},
  pages={
          C865-73
        }
}
Atherosclerosis is a complex chronic inflammatory disease in which macrophages play a critical role, and the intervention of the inflammatory process in atherogenesis could be a therapeutic strategy. In this study, we investigated the efficacy of xenogenic macrophage immunization on the atherosclerotic lesion formation in a model of murine atherosclerosis. Apolipoprotein E knockout (apoE-KO) mice were repeatedly immunized with formaldehyde-fixed cultured human macrophages (phorbol ester… Expand

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