Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism.

@article{ButeauLozano2008XenoestrogensMV,
  title={Xenoestrogens modulate vascular endothelial growth factor secretion in breast cancer cells through an estrogen receptor-dependent mechanism.},
  author={H{\'e}l{\`e}ne Buteau-Lozano and Guillaume Velasco and Monique Cristofari and Patrick Balaguer and Martine Perrot-Applanat},
  journal={The Journal of endocrinology},
  year={2008},
  volume={196 2},
  pages={399-412}
}
Environmental chemicals may affect human health by disrupting endocrine function. Their possible role in the mammary gland and breast tumors is still unknown. Previous studies have demonstrated that vascular endothelial growth factor (VEGF), a key factor in angiogenesis and tumor progression, is an estrogen-regulated gene. We analyzed whether VEGF expression is regulated by different xenoestrogens in several breast cancer cells, MELN (derived from MCF-7) and MELP (derived from MDA-MB-231) and… CONTINUE READING
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