Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status.

@article{Wetherill2005XenoestrogenAI,
  title={Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status.},
  author={Yelena B Wetherill and Nicola L Fisher and Ann Staubach and Mark Danielsen and Ralph W. de Vere White and Karen E. Knudsen},
  journal={Cancer research},
  year={2005},
  volume={65 1},
  pages={54-65}
}
Androgen is critical for prostate development, growth, and survival. Therapies for advanced prostate cancer aim to block androgen receptor (AR) action. However, recurrent tumors ultimately arise, which harbor restored AR activity. One mechanism of such reactivation occurs through AR mutations, rendering the receptor responsive to noncanonical ligands. We have shown previously that a known xenoestrogen, bisphenol A (BPA), activates a tumor-derived AR mutant (T877A), leading to androgen… CONTINUE READING

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