Xenoendocrine disrupters-tiered screening and testing: filling key data gaps.

  title={Xenoendocrine disrupters-tiered screening and testing: filling key data gaps.},
  author={Leon Earl Gray and Joe Ostby and Val Wilson and Christy S. Lambright and Kathy L Bobseine and Phillip C. Hartig and Andrew K. Hotchkiss and Carl F W Wolf and Johnathan R Furr and Mitch D. Price and Lauren Parks and Ralph L. Cooper and Tammy E Stoker and Susan C Laws and Sigmund J. Degitz and Kathleen M. Jensen and Michael D. Kahl and Joseph J Korte and Elizabeth A. Makynen and Joseph E. Tietge and Gerald T. Ankley},
The US Environmental Protection Agency (EPA) is developing a screening and testing program for endocrine disrupting chemicals (EDCs) to detect alterations of hypothalamic-pituitary-gonadal (HPG) function, estrogen (ER), androgen (AR) and thyroid hormone synthesis and AR and ER receptor-mediated effects in mammals and other animals. High priority chemicals would be evaluated in the Tier 1 Screening (T1S) battery and chemicals positive in T1S would then be tested (Tier 2). T1S includes in vitro… CONTINUE READING


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