Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes.

@article{Kemp2005XenobioticsIH,
  title={Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes.},
  author={Daniel C Kemp and Maciej J. Zamek-Gliszczynski and Kim L R Brouwer},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={83 2},
  pages={207-14}
}
Reports suggest that troglitazone, and to a lesser extent bosentan, may alter bile acid homeostasis by inhibiting the bile salt export pump. The present studies examined the hypothesis that these xenobiotics may modulate multiple hepatic bile acid transport mechanisms. In suspended rat hepatocytes, troglitazone (10 microM) decreased the initial rate of taurocholate uptake approximately 3-fold; the initial uptake rate of estradiol-17beta-D-glucuronide, a substrate of the organic anion… CONTINUE READING

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