Xenobiotic oxidation during early pregnancy in man: peroxidase catalysed chemical oxidation in conceptual tissues.

@article{Joseph1994XenobioticOD,
  title={Xenobiotic oxidation during early pregnancy in man: peroxidase catalysed chemical oxidation in conceptual tissues.},
  author={P. Joseph and S. Srinivasan and A. Kulkarni},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1994},
  volume={24 7},
  pages={
          583-90
        }
}
1. A membrane-bound peroxidase activity was isolated and purified from pooled samples of human intrauterine tissue (embryo, placenta, amnion, chorion and uterine decidua) of 4-6 weeks of gestation. 2. The H2O2-dependent guaiacol oxidation catalysed by the purified peroxidase exhibited a specific activity of 10.82 +/- 1.81 mumol/min/mg protein. 3. The optimum conditions required for guaiacol oxidation catalysed by the peroxidase included 18 mM guaiacol, 400 microM H2O2, pH 9.0, and 2 micrograms… Expand
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The results suggest that peroxidase may be a major enzyme in human term placenta capable of oxidation of endogenous chemicals and xenobiotics. Expand
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