Xenobiotic metabolism in human skin and 3D human skin reconstructs: a review.

@article{Gibbs2007XenobioticMI,
  title={Xenobiotic metabolism in human skin and 3D human skin reconstructs: a review.},
  author={Sue Gibbs and Johannes J M van de Sandt and Hans Friedrich Merk and David J. Lockley and Ruth U Pendlington and Camilla K Smith Pease},
  journal={Current drug metabolism},
  year={2007},
  volume={8 8},
  pages={758-72}
}
In this review, we discuss and compare studies of xenobiotic metabolism in both human skin and 3D human skin reconstructs. In comparison to the liver, the skin is a less studied organ in terms of characterising metabolic capability. While the skin forms the major protective barrier to environmental chemical exposure, it is also a potential target organ for adverse health effects. Occupational, accidental or intended-use exposure to toxic chemicals could result in acute or delayed injury to the… CONTINUE READING

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