Xenobiotic metabolism gene expression in the EpiDermin vitro 3D human epidermis model compared to human skin.

@article{Hu2010XenobioticMG,
  title={Xenobiotic metabolism gene expression in the EpiDermin vitro 3D human epidermis model compared to human skin.},
  author={Ting Hu and Zubin S Khambatta and Patrick J. Hayden and J Bolmarcich and Robert L Binder and Matthew K. Robinson and Gregory J. Carr and Jay P. Tiesman and Bradley B Jarrold and Rosemarie Osborne and Timothy D Reichling and Stef{\'a}nia N{\'e}meth and Marilyn J. Aardema},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 5},
  pages={1450-63}
}
There is an urgent need to validate in vitro human skin models for use in safety testing. An important component of validation is characterizing the metabolizing capacity of these models. We report comparison of the expression of 139 genes encoding xenobiotic metabolizing enzymes in the EpiDerm model and human skin. In microarray analysis, the expression of 87% of the genes was consistent between the EpiDerm model and human skin indicating the presence of similar metabolic pathways suggesting… CONTINUE READING