Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible.

@article{Amano2004XenobioticinducedLO,
  title={Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible.},
  author={Katsushi Amano and Patrick S. C. Leung and Qingchai Xu and Jan Mar{\'i}k and Chao Quan and Mark J Kurth and Michael H Nantz and Aftab A Ansari and Kit Sang Lam and Mikio Zeniya and Ross L Coppel and M Eric Gershwin},
  journal={Journal of immunology},
  year={2004},
  volume={172 10},
  pages={6444-52}
}
Previous work has demonstrated that immunization of rabbits with the xenobiotic 6-bromohexanoate coupled to BSA breaks tolerance and induces autoantibodies to mitochondria in rabbits. Such immunized rabbits develop high-titer Abs to pyruvate dehydrogenase complex (PDC)-E2, the major autoantigen of primary biliary cirrhosis. In efforts to map the fine specificity of these autoantibodies, rabbits were immunized biweekly with 6-bromohexanoate-BSA and screened for reactivity using a unique… CONTINUE READING

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