Xenobiotic acyl-coenzymes A : critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids

@inproceedings{John2009XenobioticAA,
  title={Xenobiotic acyl-coenzymes A : critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids},
  author={John},
  year={2009}
}
ronidazole. The reduction of the nitro group to the amine cesults in the total loss of mutagenic activity. Furthermore, once the amine is formed, it is not re-activated like those of other aromatic amines. In conclusion, the major ronidazole-protein adduct contains a reduced nitro function, has lost the carbamoyl group, and is alkylated by cysteine at the 2-methylene or 4-position. These structural alterations strongly suggest that the protein-bound adduct has lost all the mutagenic potential… CONTINUE READING

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Bwchem . Pharmacol

J. Caldwell, J. R. Idle, R. L. Smith
1983

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