Xeno-repopulation of Fah−/−Nod/Scid mice livers by human hepatocytes

@article{Su2011XenorepopulationOF,
  title={Xeno-repopulation of Fah−/−Nod/Scid mice livers by human hepatocytes},
  author={BaoLiang Su and Changcheng Liu and Dao Xiang and Haibin Zhang and Siming Yuan and Minjun Wang and Fei Chen and Haiying Zhu and Zhiying He and Xin Wei Wang and Yiping Hu},
  journal={Science China Life Sciences},
  year={2011},
  volume={54},
  pages={227-234}
}
Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics, infection of hepatitis viruses, and the efficacy of hepatitis vaccines. Significant levels of liver xeno-repopulation have been reported in Fah−/−Rag2−/−Il2rg−/− mice. However, the high mortality and low breeding rate of this model may hinder its application. A new model, termed Fah−/−Nod/Scid mice, which combines the advantages of liver repopulation in Fah−/− mice with the… CONTINUE READING
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