Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.

@article{Williams2014Xbp1sIP,
  title={Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis.},
  author={Kevin W. Williams and Tiemin Liu and Xingxing Kong and Makoto Fukuda and Yingfeng Deng and Eric D. Berglund and Zhuo Deng and Yong Hui Gao and Tianya Liu and Jong-woo Sohn and Lin Jia and Teppei Fujikawa and Daisuke Kohno and Michael M. Scott and Syann Lee and Charlotte Lee and Kai Sun and Yongsheng Chang and Philipp E Scherer and Joel K Elmquist},
  journal={Cell metabolism},
  year={2014},
  volume={20 3},
  pages={
          471-82
        }
}
The molecular mechanisms underlying neuronal leptin and insulin resistance in obesity and diabetes remain unclear. Here we show that induction of the unfolded protein response transcription factor spliced X-box binding protein 1 (Xbp1s) in pro-opiomelanocortin (Pomc) neurons alone is sufficient to protect against diet-induced obesity as well as improve leptin and insulin sensitivity, even in the presence of strong activators of ER stress. We also demonstrate that constitutive expression of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 57 CITATIONS, ESTIMATED 40% COVERAGE

"Hypothalamic Microinflammation" Paradigm in Aging and Metabolic Diseases.

Dongsheng Cai, Sinan Khor
  • Cell metabolism
  • 2019
VIEW 6 EXCERPTS
HIGHLY INFLUENCED

Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia

  • Diabetes
  • 2017
VIEW 12 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons.

  • Cell reports
  • 2017
VIEW 4 EXCERPTS
CITES METHODS & RESULTS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2015
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations

  • Averaged 10 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 70 REFERENCES

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism.

  • The Journal of clinical investigation
  • 2013
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Obesity is associated with hypothalamic injury in rodents and humans.

  • The Journal of clinical investigation
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A guide to analysis of mouse energy metabolism

  • Nature Methods
  • 2011
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…