Xanthohumol improved cognitive flexibility in young mice

  title={Xanthohumol improved cognitive flexibility in young mice},
  author={Daniel R. Zamzow and V. D. Elias and Leecole L Legette and Jaewoo Choi and Jan F. Stevens and Kathy Ruth Magnusson},
  journal={Behavioural Brain Research},
The protein palmitoylation cycle has been shown to be important for protein signaling and synaptic plasticity. Data from our lab showed a change in the palmitoylation status of certain proteins with age. A greater percentage of the NMDA receptor subunits GluN2A and GluN2B, along with Fyn and PSD95 proteins, were palmitoylated in the old mice. The higher level of protein palmitoylation was also associated with poorer learning scores. Xanthohumol is a prenylated flavonoid that has been shown to… CONTINUE READING


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