Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration

@inproceedings{Henneman2018XanthohumolPM,
  title={Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration},
  author={Nathaniel Fath Henneman and Stephanie Foster and Micah A. Chrenek and Jana T. Sellers and Charles R. B. Wright and Robin H. Schmidt and John M. Nickerson and Jeffrey H. Boatright},
  booktitle={Investigative ophthalmology & visual science},
  year={2018}
}
Purpose To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is protective in a mouse model of light-induced retinal degeneration (LIRD). Methods Mice (129S2/SvPasCrl) were intraperitoneally injected with vehicle or XN prior to toxic light exposure and every 3 days thereafter. Retinal function was assessed by electroretinograms at 1, 2, and 4 weeks following toxic light exposure. Visual acuity was tested by optokinetic… CONTINUE READING
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