Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells.

@article{Kunnimalaiyaan2015XanthohumolMediatedSO,
  title={Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells.},
  author={Selvi Kunnimalaiyaan and Jose G. Trevino and Susan Tsai and T Clark Gamblin and Muthusamy Kunnimalaiyaan},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 6},
  pages={1395-403}
}
Pancreatic cancer remains a lethal disease with limited treatment options. At the time of diagnosis, approximately 80% of these patients present with unresectable tumors caused by either locally advanced lesions or progressive metastatic growth. Therefore, development of novel treatment strategies and new therapeutics is needed. Xanthohumol (XN) has emerged… CONTINUE READING