Xanthohumol, a prenylated chalcone from beer hops, acts as an α-glucosidase inhibitor in vitro.

@article{Liu2014XanthohumolAP,
  title={Xanthohumol, a prenylated chalcone from beer hops, acts as an α-glucosidase inhibitor in vitro.},
  author={Milun Liu and Hua Chuan Yin and Ge Liu and Jianjun Dong and Zhonghua Qian and Jinlai Miao},
  journal={Journal of agricultural and food chemistry},
  year={2014},
  volume={62 24},
  pages={
          5548-54
        }
}
Xanthohumol (XN) is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. XN alleviates hyperglycemia and has potential usage in the treatment of type 2 diabetes. In the present study, a series of in vitro experiments were performed to investigate whether XN was an effective inhibitor of α-glucosidase. The results showed that XN inhibited α-glucosidase in a reversible and noncompetitive manner, with an IC50 value of 8.8 μM and that XN inhibited the release of glucose from the… CONTINUE READING
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