Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor.

@article{Wang2012XanthohumolAP,
  title={Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor.},
  author={Yidan Wang and Yong Chen and Jia-Huai Wang and Jun Chen and Bharat Bhushan Aggarwal and Xiaowen Pang and Mingyao Liu},
  journal={Current molecular medicine},
  year={2012},
  volume={12 2},
  pages={153-62}
}
Cancer metastasis is the main cause of death (90%), and only recently we have gained some insight into the mechanisms by which metastatic cells arise from primary tumors and target to specific organs. Cysteine X Cysteine (CXC) chemokine receptor 4 (CXCR4), initially linked with leukocyte trafficking, is overexpressed in various tumors and mediates homing of tumor cells to distant sites expressing its cognate ligand CXCL12. Therefore, identification of CXCR4 inhibitors has great potential to… CONTINUE READING
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