Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}.

@article{Gibbings2011XanthineOP,
  title={Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-\{gamma\} sumoylation, and HIF-1\{alpha\}.},
  author={Sophie Gibbings and Nancy D. Elkins and Hillary Fitzgerald and J Tiao and Mari E Weyman and Gayle N. Shibao and Mehdi A. Fini and Richard M. Wright},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 2},
  pages={961-75}
}
The protective effects of pharmacological inhibitors of xanthine oxidoreductase (XOR) have implicated XOR in many inflammatory diseases. Nonetheless, the role played by XOR during inflammation is poorly understood. We previously observed that inhibition of XOR within the inflammatory mononuclear phagocytes (MNP) prevented neutrophil recruitment during adoptive transfer demonstrating the role of XOR in MNP-mediated neutrophil recruitment. To further explore the role of XOR in the inflammatory… CONTINUE READING

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