Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.

  title={Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.},
  author={Kevin Cheung and Iphigenia Tzameli and Pavlos Pissios and I. Rovira and Oksana Gavrilova and Toshio Ohtsubo and Zhu Chen and Toren Finkel and Jeffrey S. Flier and Jeffrey M. Friedman},
  journal={Cell metabolism},
  volume={5 2},
In an effort to identify novel candidate regulators of adipogenesis, gene profiling of differentiating 3T3-L1 preadipocytes was analyzed using a novel algorithm. We report here the characterization of xanthine oxidoreductase (XOR) as a novel regulator of adipogenesis. XOR lies downstream of C/EBPbeta and upstream of PPARgamma, in the cascade of factors that control adipogenesis, and it regulates PPARgamma activity. In vitro, knockdown of XOR inhibits adipogenesis and PPARgamma activity while… CONTINUE READING
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