Xanthine oxido-reductase activity in ischemic human and rat intestine.

@article{Bianciardi2004XanthineOA,
  title={Xanthine oxido-reductase activity in ischemic human and rat intestine.},
  author={Paola Bianciardi and Roberto Scorza and Giorgio Ghilardi and Michele Samaja},
  journal={Free radical research},
  year={2004},
  volume={38 9},
  pages={
          919-25
        }
}
  • Paola Bianciardi, Roberto Scorza, +1 author Michele Samaja
  • Published in Free radical research 2004
  • Chemistry, Medicine
  • We measured time course and extent of xanthine dehydrogenase (XD) to xanthine oxidase (XO) conversion in ischemic human and rat intestine. To model normothermic no-flow ischemia, we incubated fresh biopsies for 0, 2, 4, 8 and 16h. At t = 0h, XO was less in humans than in rats (P < 0.0004), while XD was essentially the same (P = NS). After 16h incubation at 37 degrees C, there was no appreciable XD-to-XO conversion and no change in neither XO nor XD activity in human intestine. In contrast, the… CONTINUE READING

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