Xanthine oxidase released from reperfused hind limbs mediate kupffer cell activation, neutrophil sequestration, and hepatic oxidative stress in rats subjected to tourniquet shock.

@article{Vega2000XanthineOR,
  title={Xanthine oxidase released from reperfused hind limbs mediate kupffer cell activation, neutrophil sequestration, and hepatic oxidative stress in rats subjected to tourniquet shock.},
  author={Vivian Vega and Lorena Mardones and M. Loreto Hernandez Maldonado and S M Nicovani and Viviana Manr{\'i}quez and Juan Roa and Paul H. Ward},
  journal={Shock},
  year={2000},
  volume={14 5},
  pages={565-71}
}
We have shown previously that rats subjected to tourniquet shock develop an acute form of remote organ injury of the liver that is both Kupffer cell (KC) and polymorphonuclear (PMN) leukocyte dependent. Circulating plasma xanthine oxidase (XO) has been shown to be responsible for the development of endothelial dysfunction and for remote organ injury of the lung and intestine after ischemia-reperfusion protocols. We now hypothesize that XO is released from rat hind limbs upon reperfusion and… CONTINUE READING

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