Xanthine oxidase inhibitory triterpenoid and phloroglucinol from guttiferaceous plants inhibit growth and induced apoptosis in human NTUB1 cells through a ROS-dependent mechanism.

@article{Lin2011XanthineOI,
  title={Xanthine oxidase inhibitory triterpenoid and phloroglucinol from guttiferaceous plants inhibit growth and induced apoptosis in human NTUB1 cells through a ROS-dependent mechanism.},
  author={K C Lin and A-Mei Huang and Huang-Yao Tu and Ling-Yi Lee and Chien-Chang Wu and T C Hour and S S Yang and Y K Pu and Chun-Nan Lin},
  journal={Journal of agricultural and food chemistry},
  year={2011},
  volume={59 1},
  pages={407-14}
}
A known triterpenoid, β-amyrin (1), and a known and a new phloroglucinol, cohulupone (2) and garcinielliptone P (3), were isolated from the pericarp and heartwood and seed of Garcinia subelliptica, respectively. A new xanthonolignoid, hyperielliptone HF (4), was isolated from the heartwood of Hypericum geminiflorum. The new compounds were established by analysis of their spectroscopic data. Compounds 1-3 showed an inhibitory effect on xanthine oxidase (XO). Treatment of NTUB1, a human bladder… CONTINUE READING
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