Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.

@article{Kumagai2002XanthineOI,
  title={Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism.},
  author={Akiko Kumagai and Hideya Kodama and Jin Kumagai and Jun Fukuda and Kazuhiro Kawamura and Hideo Tanikawa and Naoki Sato and Toshinobu Tanaka},
  journal={Molecular human reproduction},
  year={2002},
  volume={8 2},
  pages={118-23}
}
Apoptotic degeneration of germ cells in cryptorchid testis is associated with an increased level of reactive oxygen species, and may be prevented by antioxidant treatment. The objective of this study was to investigate whether xanthine oxidase inhibitors could confer such protection. Unilateral cryptorchidism was surgically induced in the immature rats, which were then left untreated or treated with xanthine oxidase inhibitors, and the testes were evaluated 7 days after the operation. In the… CONTINUE READING
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