Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study.

@article{Scheepers2016XanthineOG,
  title={Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study.},
  author={Lieke E. J. M. Scheepers and F Y Wei and Katarzyna Stolarz-Skrzypek and Sofia Malyutina and Val{\'e}rie Tikhonoff and Lutgarde Thijs and Erika Salvi and Cristina Barlassina and Jan Filipovsk{\'y} and Edoardo Casiglia and Yuri S. Nikitin and Kalina Kawecka-Jaszcz and Paolo Manunta and Daniele Cusi and Annelies Boonen and Jan A Staessen and Ilja C. W. Arts},
  journal={Journal of hypertension},
  year={2016},
  volume={34 11},
  pages={2147-54}
}
OBJECTIVE The enzyme xanthine oxidoreductase (XOR) generates uric acid in the terminal steps of the purine metabolism; meanwhile reactive oxygen species are formed. We hypothesized that uric acid production, as assessed indirectly from XOR variants, is associated with hypertension. METHODS Among 2769 participants (48.3% men; mean age 40.7 years) randomly recruited from European populations, we genotyped 25 tagging XOR SNPs and measured blood pressure (BP) at baseline and follow-up (median 8.8… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS