Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells.

@article{Griguer2006XanthineOR,
  title={Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells.},
  author={Corinne E Griguer and Claudia R. Oliva and Eric E. Kelley and Gregory I. Giles and Jack R. Lancaster and George Yancey Gillespie},
  journal={Cancer research},
  year={2006},
  volume={66 4},
  pages={2257-63}
}
During chemical hypoxia induced by cobalt chloride (CoCl2), hypoxia-inducible factor 1alpha (HIF1-alpha) mediates the induction of a variety of genes including erythropoietin and vascular endothelial growth factor. We used glioma cells with oxidative phosphorylation-dependent (D54-MG) and glycolytic-dependent (U251-MG) phenotypes to monitor HIF1-alpha regulation in association with redox responsiveness to CoCl2 treatment. We showed that CoCl2 increased xanthine oxidase (XO)-derived reactive… CONTINUE READING
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