Xanthine oxidase and activated neutrophils cause oxidative damage to skeletal muscle after contractile claudication.

  title={Xanthine oxidase and activated neutrophils cause oxidative damage to skeletal muscle after contractile claudication.},
  author={Andrew R. Judge and Stephen L. Dodd},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={286 1},
  • A. JudgeS. Dodd
  • Published 2004
  • Biology
  • American journal of physiology. Heart and circulatory physiology
We previously showed oxidative damage and edema within skeletal muscle after contractile claudication. To investigate the sources of this oxidative damage in the gastrocnemius muscle, we administered allopurinol (Allo, to inhibit xanthine oxidase) and cyclophosphamide (Cyclo, to deplete neutrophils) before inducing contractile claudication in male Sprague Dawley rats. Contractile claudication (ligated stimulated, LS) caused a significant increase in xanthine oxidase activity [sham ligated… 

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