Xanthine derivatives in the heart: blessed or cursed?

  title={Xanthine derivatives in the heart: blessed or cursed?},
  author={Andr{\'a}s J{\'o}zsef Szentmikl{\'o}si and Agnes Cseppent{\~o} and Rudolf Gesztelyi and Judit Zsuga and Agnes K{\"o}rtv{\'e}ly and G{\'a}bor Harmati and P{\'e}ter P{\'a}l N{\'a}n{\'a}si},
  journal={Current medicinal chemistry},
  volume={18 24},
Methylxanthines, such as theophylline, have been used to treat cardiorespiratory disorders, whereas caffeine is the most widely consumed psychoactive agent in various soft drinks. Because of the worldwide use of these drugs and the recently synthesized xanthine derivatives, an intensive research on the cardiac actions of these substances is under progress. This review focuses on the molecular mechanisms involved in the actions of xanthine derivatives with special reference to their adenosine… CONTINUE READING
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