Xanthine dehydrogenase expression inNeurospora crassa does not require a functionalnit-2 regulatory gene

@article{Griffith1988XanthineDE,
  title={Xanthine dehydrogenase expression inNeurospora crassa does not require a functionalnit-2 regulatory gene},
  author={Anne Barnet Griffith and Reginald H. Garrett},
  journal={Biochemical Genetics},
  year={1988},
  volume={26},
  pages={37-52}
}
Xanthine dehydrogenase (XDH) is the initial enzyme in the purine catabolic pathway ofN. crassa. Secondary nitrogen sources such as purines are metabolized when preferred sources of reduced nitrogen (ammonium or glutamine) are unavailable. XDH synthesis is regulated by glutamine repression and uric acid induction. Thenit-2 locus is believed to encode atrans-acting positive regulator essential for the expression of genes encoding enzymes involved in secondary pathways of nitrogen acquisition… CONTINUE READING

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