Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation.

@article{Pfeffer1994XanthineDA,
  title={Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation.},
  author={K D Pfeffer and Thomas P. Huecksteadt and John R. Hoidal},
  journal={Journal of immunology},
  year={1994},
  volume={153 4},
  pages={1789-97}
}
Reactive oxygen species have been implicated in the tissue injury and loss of epithelial barrier function associated with a number of clinical disorders in which disregulated inflammation seems to be a dominant event, such as endotoxemia and viral syndromes. In these disorders, xanthine oxidase (XO) contained within the epithelial cell has been proposed as a major source of injurious reactive oxygen species. This study was undertaken in an effort to understand the regulation of xanthine… CONTINUE READING