Xanthine analysis in biological fluids by capillary electrophoresis.

  title={Xanthine analysis in biological fluids by capillary electrophoresis.},
  author={Zakariya Kamel Shihabi and Myron E. Hinsdale and Anthonny J Bleyer},
  journal={Journal of chromatography. B, Biomedical applications},
  volume={669 1},
Xanthine, a precursor of uric acid, is measured here in serum, urine, and cerebrospinal fluids by capillary electrophoresis (CE) after deproteinization with acetonitrile. The migration time is about 7.5 min with a minimum detection limit of 0.4 mg/l. Different purines and pyrimidines did not interfere with the determination. The method demonstrates the suitability of the CE for determination of small molecules present in a complex matrix at levels of ca. 1mg/l. It also demonstrates that… CONTINUE READING