Xanthine Oxidase-mediated Decomposition ofS-Nitrosothiols*

  title={Xanthine Oxidase-mediated Decomposition ofS-Nitrosothiols*},
  author={Madia Trujillo and Mar{\'i}a Noel {\'A}lvarez and Gonzalo Peluffo and Bruce A. Freeman and Rafael Radi},
  journal={The Journal of Biological Chemistry},
  pages={7828 - 7834}
S-Nitrosothiols (RSNO) occur in vivo and have been proposed as nitric oxide (⋅NO) storage and transport biomolecules. Still, the biochemical mechanisms by which RSNO release ⋅NO in biological systems are not well defined, and in particular, the interactions between reactive oxygen species and RSNO have not been studied. In this work, we show that xanthine oxidase (XO), in the presence of purine (hypoxanthine, xanthine) or pteridine (lumazine) substrates, induces S-nitrosocysteine (CysNO) and S… 

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