Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

  title={Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice},
  author={Johji Nomura and Nathalie Busso and Annette Ives and Chieko Matsui and Syunsuke Tsujimoto and Takashi Shirakura and Mizuho Tamura and Tsunefumi Kobayashi and Alexander Kai-Lik So and Yoshihiro Yamanaka},
  booktitle={Scientific reports},
Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate in the inflammatory process, including oxidative stress. Xanthine oxidase (XO) is a major source of reactive oxygen species (ROS) and has been linked to the pathogenesis of atherosclerosis, but the underlying mechanisms remain unclear. Here, we show enhanced XO expression in macrophages in the atherosclerotic plaque and in aortic endothelial cells in ApoE(-/-) mice… CONTINUE READING
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