Xanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a)

@article{zdl2008XanthelasmaPA,
  title={Xanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a)},
  author={Sevil {\"O}zd{\"o}l and Sedef Şahin and Lale S Tokg{\"o}zoğlu},
  journal={International Journal of Dermatology},
  year={2008},
  volume={47}
}
Objectives  To investigate the association between xanthelasma, atherosclerotic risk factors, and lipoprotein (Lp) (a), and to determine whether xanthelasma may be a cutaneous marker for atherosclerosis. 
Are normolipidaemic patients with xanthelasma prone to atherosclerosis?
When patients with xanthelasma are found to have normal lipid levels, dermatologists usually proceed with their treatment without further investigations. However, there is some evidence thatExpand
Clinical and serum lipid profiles and LDLR genetic analysis of xanthelasma palpebrarum with nonfamilial hypercholesterolemia
TLDR
XP is a flat xanthoma that usually presents as bilateral, symmetrical, soft, yellowish papules over the eyelids, and may be related to complex heterozygous mutations. Expand
Xanthelasma palpebrarum: a marker of premature atherosclerosis (risk of atherosclerosis in xanthelasma)
TLDR
Alteration in apolipoprotein levels (A1 and B) in XP patients may predispose to cutaneous and systemic deposition of lipids, including atherosclerosis, and XP patients irrespective of their lesion size or serum lipid levels should be screened using CIMT for detection of subclinical Atherosclerosis. Expand
Xanthelasma Palpebrarum is Associated with Higher Levels of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio
Objective According to many epidemiologic studies, Xanthelasma Palpebrarum (XP) is thought to be a determinant of an increased risk of atherosclerosis. Many studies have show that inflammation playsExpand
Serum lipids and risk of atherosclerosis in xanthelasma palpebrarum: A systematic review and meta-analysis.
TLDR
Patients with XP had significantly higher serum levels of atherogenic LDLs and bear significantly higher risk of atherosclerosis than the controls, and careful monitoring and targeted intervention for prevention of cardiovascular diseases is essential for these patients. Expand
Familial Xanthelasma with Dyslipidemia: Just Another Family Trait?
TLDR
A 35-year-old nonsmoker, nonalcoholic, nonhypertensive, nondiabetic male presented with chest pain and was diagnosed to have acute ST elevation inferior wall myocardial infarction. Expand
Cutaneous manifestations of obesity and themetabolic syndrome.
The cutaneous manifestations of obesity and the associated metabolic syndrome (MetS) may present with a wide variety of cutaneous findings, including acanthosis nigricans, acrochordon, cellulitis,Expand
A BIOCHEMICAL PROFILE ON PATIENTS WITH XANTHELASMA PALPEBRARUM: A CLINICAL STUDY
TLDR
There is a significant elevation in total cholesterol and LDL cholesterol in Xanthelasma palpebrarum patients as compared to controls, thus making lipid profile compulsory for all patients with X anthelasma. Expand
The Correlation Between Lipid Profile and Xanthelasma
TLDR
There was a correlation between higher cholesterol and LDL serum level with xanthelasma in Dr. M. Djamil Hospital, Padang, but there was no correlation between lower HDL and a higher triglyceride serum levelWith xant Helasma. Expand
Association of Xanthelasma palpebrarum (XP) with cardiovascular disease (CVD) risk factors
TLDR
The study reveals an increased presence of cardiovascular disease risk factors among patients with xanthelasma and a statistically significant association of gender, BMI, angina history, and serum LDL with XP were observed. Expand
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References

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Apolipoprotein E polymorphism and lipoprotein compositions in normolipidaemic xanthelasma patients
TLDR
The objective was to establish anaplipoprotein E phenotypes and lipoprotein compositions in xanthelasma patients that have been reported in different series and establish a baseline for these phenotypes to be determined in future studies. Expand
The pathogenesis and clinical significance of xanthelasma palpebrarum.
  • R. Bergman
  • Biology, Medicine
  • Journal of the American Academy of Dermatology
  • 1994
Xanthelasma palpebrarum is the most common type of xanthoma. On average, only half the patients with xanthelasma palpebrarum are hyperlipidemic. This review is an attempt to elucidate theExpand
Clinical observations regarding xanthelasma.
Excerpt Xanthelasma or xanthoma palpebrarum (figure 1) has been reported as being encountered more frequently than is any other type of cutaneous xanthoma.1It has been noted to occur in many types ...
Serum lipoproteins and cholesterol metabolism in xanthelasma.
TLDR
Observations of 35 patients with xanthelasma, obtained mainly from the private dermatologic practice of one of us, found the serum of such patients with respect to lipoproteins which appear to be in some way associated with atherosclerosis to be of particular importance. Expand
Increased Frequency of Apo E-ND phenotype and hyperapobeta-lipoproteinemia in normolipidemic subjects with xanthelasmas of the eyelids.
TLDR
This is the first report of an increased frequency of the apolipoprotein E-ND phenotype in normolipidemic xanthelasma, and tissue lipid deposition in the absence of hyperlipidemia might be related to the presence of lipoproteins of abnormal composition with an enhanced atherogenic potential. Expand
Lipid metabolism and apolipoprotein E phenotypes in patients with xanthelasma.
TLDR
The findings support the notion that xanthelasma is a marker of dyslipidemia, and underline the need to determine a full lipid profile in these patients to detect those potentially at increased risk of cardiovascular disease. Expand
Lipoprotein(a). A unique risk factor for atherothrombotic disease.
TLDR
Observations on the unique structural features of Lp(a) shed light on some possible explanations for its atherogenic potential and highlight its pathophysiologic role at the interface of atherosclerosis and thrombosis. Expand
The association of dyslipoproteinemia with corneal arcus and xanthelasma. The Lipid Research Clinics Program Prevalence Study.
TLDR
The clinical findings of xanthelasma or corneal arcus seem to identify persons with plasma lipoprotein abnormalities, especially in young people. Expand
Xanthelasma: clinical indicator of decreased levels of high-density lipoprotein cholesterol.
TLDR
This study points out the high probability of decreased HDL-C levels in patients with xanthelasma, which has been shown to be inversely related to the incidence of cardiovascular disease and Evaluation of cardiac risk showed 80% of the study population to have three to four times the average risk. Expand
Xanthelasma: clinical indicator of decreased levels of high-density lipoprotein cholesterol.
TLDR
This study points out the high probability of decreased HDL-C levels in patients with xanthelasma, which has been shown to be inversely related to the incidence of cardiovascular disease and Evaluation of cardiac risk showed 80% of the study population to have three to four times the average risk. Expand
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