Xanthan and galactomannan (from M. scabrella) matrix tablets for oral controlled delivery of theophylline.

@article{Vendruscolo2005XanthanAG,
  title={Xanthan and galactomannan (from M. scabrella) matrix tablets for oral controlled delivery of theophylline.},
  author={C W Vendruscolo and Itamar Francisco Andreazza and John Ganter and Carmen Ferrero and Tania Mari Bell{\'e} Bresolin},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={296 1-2},
  pages={1-11}
}
Directly compressed theophylline tablets, containing commercial xanthan (X) (Keltrol) and a highly hydrophilic galactomannan (G) from the seeds of Mimosa scabrella (a brazilian leguminous tree called bracatinga) as release-controlling agents, were obtained. Gums were used at 4, 8, 12.5 and 25% (w/w), either alone or in mixture (X:G 1:1). During galactomannan extraction process, the biopolymer was dried in a scale up, by vacuum oven (VO) or spray dryer (SD). The in vitro drug release was… CONTINUE READING
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