Xaf1 can cooperate with TNFα in the induction of apoptosis, independently of interaction with XIAP

@article{Xia2005Xaf1CC,
  title={Xaf1 can cooperate with TNFα in the induction of apoptosis, independently of interaction with XIAP},
  author={Yan Xia and Rachel Novak and Jennifer J Lewis and Colin S. Duckett and Andrew C. Phillips},
  journal={Molecular and Cellular Biochemistry},
  year={2005},
  volume={286},
  pages={67-76}
}
XIAP-associated factor 1 (Xaf1) binds XIAP and re-localizes it to the nucleus, thus inhibiting XIAP activity and enhancing apoptosis [1]. Xaf1 expression is reduced or absent in tumor samples and cell lines suggesting it may function as a tumor suppressor [2–5]. To further study Xaf1 function we generated Xaf1 inducible cells in the osteosarcoma cell line Saos-2. Despite Xaf1 inducing apoptosis that is dramatically enhanced by TNFα we find no evidence for an interaction between Xaf1 and XIAP… CONTINUE READING
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