XRCC4 codon 247*A and XRCC4 promoter −1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis

@article{Hsieh2008XRCC4C2,
  title={XRCC4 codon 247*A and XRCC4 promoter −1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis},
  author={Yao Yuan Hsieh and Da-Tian Bau and Chi-chen Chang and Chang-Hai Tsai and Chih-ping Chen and Fuu-Jen Tsai},
  journal={Molecular Reproduction and Development},
  year={2008},
  volume={75}
}
DNA repair systems act to maintain genome integrity in the face of replication errors, environmental insults, and the cumulative effects of age. Genetic variants in DNA repair genes such as X‐ray repair cross‐complementing group 4 (XRCC4) might influence the ability to repair damaged DNA. Herein we aimed to investigate whether some XRCC4‐related polymorphisms were associated with endometriosis susceptibility. Women were divided: (1) severe endometriosis (rAFS stage IV, n = 136) and (2… 
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DNA Repair Gene XRCC1 and XRCC4 Variations and Risk of Endometriosis: An Association Study
TLDR
The XRCC4 -1394T/G polymorphism was associated with susceptibility to endometriosis in an Iranian population.
Association of XRCC3 and XRCC4 gene polymorphisms, family history of cancer and tobacco smoking with non-small-cell lung cancer in a Chinese population: a case–control study
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It is suggested that SNPs of XRCC3 andXRCC4 and other environmental factors are risk factors for developing NSCLC in this Chinese Han population.
Role of the functional variant (−652T>G) in the XRCC4 promoter in prostate cancer
TLDR
The data suggest that the XRCC4 promoter −652G>T polymorphism is functional and may influence genetic susceptibility to prostate cancer.
Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer.
TLDR
An increased average of chromosome breakage in bleomycin-treated lymphocytes from patients with endometriosis and ovarian cancer compared with healthy women and significant association between XRCC1,XRCC3, and BLHX polymorphisms and a high frequency of chromosomal damage was detected.
Susceptibility to Breast Cancer and Intron 3 Ins/Del Genetic Polymorphism of DNA Double-Strand Break Repair Gene XRCC4
TLDR
Although there was no significant association between XRCC4 I/D polymorphism and risk of breast cancer, patients having the II genotype have lower age at diagnosis in comparison with patients having ID+DD genotypes.
Allelic prevalence of intron 3 insertion/deletion genetic polymorphism of DNA double-strand break repair gene XRCC4 in four healthy Iranian populations
Genetic variants in the nucleotide excision repair genes are associated with the risk of developing endometriosis
TLDR
Genetic variants in the nucleotide excision repair genes, such as ERCC1, ERCC2, and ERCC6, may contribute to the development of endometriosis, which is a major health issue among women of reproductive age.
The role of apurinic/apyrimidinic endonuclease DNA repair gene in endometriosis.
TLDR
The APEX1 Asp(148)Glu genotype correlates well with its mRNA and protein expression among endometriosis patients and may not serve as a sensitive marker for prediction of endometRIosis risk in Taiwan.
Association of p 53 and CDKN 1 A Genotypes with Endometriosis
TLDR
The findings suggest that the C (Pro) allele of p53 codon 72 may be associated with the development of endometriosis, and could serve as a potential biomarker for early prediction of this disease.
Association of p53 and CDKN1A genotypes with endometriosis.
TLDR
The findings suggest that the C (Pro) allele of p53 codon 72 may be associated with the development of endometriosis, and could serve as a potential biomarker for early prediction of this disease.
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