XRCC2 and XRCC3 Gene Polymorphismand Risk of Pancreatic Cancer

  title={XRCC2 and XRCC3 Gene Polymorphismand Risk of Pancreatic Cancer},
  author={Li Jiao and Manal M. Hassan and Melissa L Bondy and Robert A. Wolff and Douglas B. Evans and James L Abbruzzese and Dong-hui Li},
  journal={The American Journal of Gastroenterology},
OBJECTIVESXRCC2 and XRCC3 are key components of the homologous recombination (HR) machinery that repairs DNA double-strand breaks. We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer.METHODSIn a hospital-based case-control study, genomic DNA and exposure information was obtained from 468 patients with pathologically confirmed pancreatic adenocarcinoma and 498 frequency… CONTINUE READING


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