XRCC2 and XRCC3 Gene Polymorphismand Risk of Pancreatic Cancer

@article{Jiao2008XRCC2AX,
  title={XRCC2 and XRCC3 Gene Polymorphismand Risk of Pancreatic Cancer},
  author={Li Jiao and Manal M. Hassan and Melissa L Bondy and Robert A. Wolff and Douglas B. Evans and James L Abbruzzese and Dong-hui Li},
  journal={The American Journal of Gastroenterology},
  year={2008},
  volume={103},
  pages={360-367}
}
OBJECTIVESXRCC2 and XRCC3 are key components of the homologous recombination (HR) machinery that repairs DNA double-strand breaks. We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer.METHODSIn a hospital-based case-control study, genomic DNA and exposure information was obtained from 468 patients with pathologically confirmed pancreatic adenocarcinoma and 498 frequency… CONTINUE READING

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References

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Showing 1-10 of 36 references

The XPD Asp (312)Asn and Lys(751)Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk

  • L Jiao, MM Hassan, ML Bondy
  • Cancer Lett 2006;245:61–8
  • 2006
2 Excerpts

facts and figures: 2006

  • ACS. Cance
  • Atlanta, GA: American Cancer Society,
  • 2006
1 Excerpt

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