XRCC1 rs25487 genetic variant and TP53 mutation at codon 249 predict clinical outcomes of hepatitis B virus-related hepatocellular carcinoma after hepatectomy: A cohort study for 10 years' follow up.

@article{Yu2016XRCC1RG,
  title={XRCC1 rs25487 genetic variant and TP53 mutation at codon 249 predict clinical outcomes of hepatitis B virus-related hepatocellular carcinoma after hepatectomy: A cohort study for 10 years' follow up.},
  author={Long Yu and Xiaoguang Liu and Chuangye Han and Sichong Lu and Guangzhi Zhu and Hao Hui Su and Wei Qi and Xiwen Liao and Tao Peng},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2016},
  volume={46 8},
  pages={765-74}
}
AIM To investigate the effects of rs25487 (the DNA repair gene: x-ray repair complementing defective repair in Chinese hamster cells 1 [XRCC1]) and codon 249 mutation (TP53 gene) on clinical outcomes of post-hepatectomy hepatitis B virus (HBV)-related HCC. METHODS The XRCC1 rs25487 polymorphism and TP53 mutation at codon 249 of 485 hepatitis B surface antigen positive patients subjected to hepatectomy were genotyped via direct sequencing. SPSS software version 16.0 (SPSS, Chicago, IL, USA… CONTINUE READING

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