XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia

@article{Bnescu2014XRCC1AA,
  title={XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia},
  author={Claudia Bănescu and Carmen Duicu and Adrian Pavel Trifa and Minodora Dobreanu},
  journal={Leukemia \& Lymphoma},
  year={2014},
  volume={55},
  pages={365 - 370}
}
Abstract In the base excision repair pathway, the predominant DNA damage repair mechanism, X-ray repair cross-complementing group 1 (XRCC1) gene, has a crucial role. Defects in repair pathways are involved in cancer pathogenesis. Therefore, DNA repair genes might be involved in acute myeloid leukemia (AML) susceptibility. Our study aimed to evaluate the relationship between XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms and AML. Sixty-nine patients with AML and 147 healthy controls were… 
XRCC1 Arg194Trp and XRCC1 Arg399Gln Polymorphisms Affect Clinical Features and Prognosis of Myelodysplastic Syndromes
TLDR
Two studies suggest that XRCC1 polymorphisms affected clinical features of MDS and may be useful prognostic marker for MDS.
Risk effects of XRCC1 Arg399Gln and XPD Lys751Gln gene polymorphisms in de novo acute myeloid leukemia – A study from India
TLDR
Findings suggests that genetic polymorphism in the DNA repair genes may modulate susceptibility to AML.
Age- and Gender-Independent Association of XRCC1 Arg399Gln Polymorphism with Chronic Myeloid Leukemia
TLDR
XRCC1 Arg399Gln gene polymorphism might have an important role in increasing the risk of chronic myeloid leukemia among Sudanese patients.
Polymorphism of XRCC1, XRCC3, and XPD Genes and Risk of Chronic Myeloid Leukemia
TLDR
The results suggest that the XPD Lys751Gln variant genotype increases the risk of CML.
X-ray cross-complement 1 gene polymorphisms (Arg399Gln and Arg194Trp) in patients with acute myeloid leukemia
TLDR
Individuals with mutant Trp194Trp allele had a higher risk to develop AML and that the Trp 194Arg+Trp194 Trp genotype could predict poor prognosis in AML patients, suggesting XRCC1 polymorphism to be a novel target for new effective therapies of AML.
The Arg399Gln polymorphism in the XRCC1 gene is associated with increased risk of hematological malignancies
TLDR
The current meta-analysis indicated that the Arg399Gln polymorphism in the XRCC1 gene might be a risk factor for hematological malignancies in Asians or for leukemia, and more large-scale case–control studies are needed to validate these results.
The association between the Arg280His polymorphism in the XRCC1 gene and the risk of hematological malignancies
TLDR
The current meta-analysis indicated that the Arg280His polymorphism in the XRCC1 gene might not be a risk factor for hematological malignancies, and more large-scale case–control studies are needed to validate these results.
The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies
TLDR
It is indicated that the XRCC1 Arg399Gln SNP is a risk factor for childhood lymphoblastic leukemia in Asians and no association was found in Caucasians between the SNP and risk of either chronic myeloid leukemia or chronic lymphocytic leukemia under any contrast model.
A meta-analysis study on XRCC 1 Arg 399 Gln polymorphism and hematological malignancies
TLDR
The results of this study indicate that XRCC1 399Gln allele among the pooled Asian population were more likely to show high risk of hematological malignancies development, especially in Asians and Leukemia.
Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case–control studies
TLDR
A meta-analysis suggests that Arg194Trp polymorphism may be associated with increased breast cancer risk, Arg194 trP polymorphism is associated with increase glioma risk among Asians, and Arg194 Trp polymorphisms is associatedwith decreased lung cancer risk among Caucasians.
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TLDR
A meta-analysis suggested that Arg399Gln was associated with a trend of increased breast cancer risk when using both dominant and recessive models, and larger scale primary studies are required to further evaluate the interaction of XRCC1 polymorphisms and Breast cancer risk in specific populations.
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TLDR
The results indicated that XRCC1 Arg194Trp and Arg399Gln SNPs might not be associated with the risk of GCA, however, smokers with His allele at codon 280 had a significantly increased risk ofGCA.
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TLDR
Evidence of a protective effect against AML in individuals with at least one copy of the variant XRCC1 399Gln allele compared with those homozygous for the common allele is provided.
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TLDR
Evidence is provided that the XRCC1 Arg399Gln polymorphism is associated with an increased risk of childhood ALL in the total population, especially Asians, and no evidence of a significant association was observed in any subgroup of the Arg194Trp polymorphism.
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TLDR
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TLDR
The analyses suggest that XRCC1 Arg194Trp, Arg280His polymorphisms may be biomarkers of cancer susceptibility and a single larger study with thousands of subjects and tissue-specific biochemical and biological characterization is warranted to further evaluate potential gene-to-gene and gene- to-environment interactions on XR CC1 polymorphisms and cancer risk.
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