XRCC 1 Polymorphisms and Cancer Risk : A Meta-analysis of 38 Case-Control Studies

@inproceedings{Hu2005XRCC1P,
  title={XRCC 1 Polymorphisms and Cancer Risk : A Meta-analysis of 38 Case-Control Studies},
  author={Zhibin Hu and Hongxia Ma and Feng Chen and Qingyi Wei and Hongbing Shen},
  year={2005}
}
Several potential functional polymorphisms (ArgTrp, ArgHis, ArgGln) in the DNA base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been implicated in cancer risk. Our meta-analysis on total of 11,957 cancer cases and 14,174 control subjects from 38 published case-control studies showed that the odds ratio (OR) for the variant genotypes (Trp/Trp + Arg/Trp) of the ArgTrp polymorphism, compared with the wild-type homozygote (Arg/Arg), was 0.89 [95% confidence interval… CONTINUE READING

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