XPORT-Dependent Transport of TRP and Rhodopsin

@article{Rosenbaum2011XPORTDependentTO,
  title={XPORT-Dependent Transport of TRP and Rhodopsin},
  author={Erica E. Rosenbaum and Kimberley S. Brehm and Eva Vasiljevic and Che-Hsiung Liu and Roger C. Hardie and Nansi Jo Colley},
  journal={Neuron},
  year={2011},
  volume={72},
  pages={602-615}
}
TRP channels have emerged as key biological sensors in vision, taste, olfaction, hearing, and touch. Despite their importance, virtually nothing is known about the folding and transport of TRP channels during biosynthesis. Here, we identify XPORT (exit protein of rhodopsin and TRP) as a critical chaperone for TRP and its G protein-coupled receptor (GPCR), rhodopsin (Rh1). XPORT is a resident ER and secretory pathway protein that interacts with TRP and Rh1, as well as with Hsp27 and Hsp90. XPORT… CONTINUE READING
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