XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes.

@article{May2012XPGAX,
  title={XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes.},
  author={N Le May and Delphine Fradin and Izarn Iltis and Pierre Bougn{\`e}res and Jean-Marc Egly},
  journal={Molecular cell},
  year={2012},
  volume={47 4},
  pages={622-32}
}
Nucleotide excision repair factors, initially characterized as part of DNA repair, have been shown to participate in the transcriptional process in the absence of genotoxic attack. However, their molecular function when recruited at the promoters of activated genes together with the transcription machinery remained obscure. Here we show that the NER factors XPG and XPF are essential for establishing CTCF-dependent chromatin looping between the promoter and terminator of the activated RARβ2 gene… CONTINUE READING
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