XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck in a Korean Sample

@inproceedings{Ji2010XPDPA,
  title={XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck in a Korean Sample},
  author={Yong Bae Ji and Kyung Tae and Yoon Seo Lee and Seung Hwan Lee and Kyung Rae Kim and Chul Won Park and Byung Park and Hyoung Doo Shin},
  booktitle={Clinical and experimental otorhinolaryngology},
  year={2010}
}
OBJECTIVES XPD is a major player in nucleotide excision repair, which is one of the basic pathways of DNA repair. The objective of this study was to investigate the association of XPD single nucleotide polymorphisms (SNPs) and the risk of squamous cell carcinoma of the head and neck (SCCHN) in Koreans. METHODS We performed XPD +23591G>A and +35931A>C genotyping in 290 SCCHN patients and 358 controls. RESULTS The frequencies of the XPD +23591G>A (GG/GA/AA) genotypes were 89.0%/11.0%/0% in… CONTINUE READING