XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis.

@article{Sturgis2000XPDERCC2PA,
  title={XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis.},
  author={Erich M Sturgis and R. J. Zheng and Li Li and Edward J. Castillo and Susan A. Eicher and Min-hu Chen and Sara S. Strom and Margaret R. Spitz and Qingyi Wei},
  journal={Carcinogenesis},
  year={2000},
  volume={21 12},
  pages={2219-23}
}
DNA repair capacity is central in maintaining normal cellular functions. Variants of several DNA repair genes,including the nucleotide excision repair gene XPD, have been described recently. Because we previously reported that patients with squamous cell carcinoma of the head and neck (SCCHN) had lower DNA repair capacity than healthy controls, we hypothesized that inherited polymorphisms of XPD may contribute to genetic susceptibility to SCCHN, a tobacco-related cancer. To test this hypothesis… CONTINUE READING

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