XIST expression from the maternal X chromosome in human male preimplantation embryos at the blastocyst stage.

@article{Ray1997XISTEF,
  title={XIST expression from the maternal X chromosome in human male preimplantation embryos at the blastocyst stage.},
  author={Patrick A. Ray and Robert M. L. Winston and Alan H. Handyside},
  journal={Human molecular genetics},
  year={1997},
  volume={6 8},
  pages={1323-7}
}
In the somatic cells of female mammals, either the maternally or paternally derived X chromosome (X(M) or X(P)) is randomly inactivated to achieve dosage compensation for X-linked genes. In early mouse development, however, selective inactivation of X(P) occurs first in extraembryonic lineages at the blastocyst stage around the time of implantation before later random inactivation in the embryonic ectoderm from which the fetus is derived. Xist, a gene mapping to the X-inactivation centre (Xic… CONTINUE READING
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