XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure

@article{Clemson1996XISTRP,
  title={XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure},
  author={Christine Moulton Clemson and John A McNeil and Huntington F. Willard and J B Lawrence},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={132},
  pages={259 - 275}
}
The XIST gene is implicated in X chromosome inactivation, yet the RNA contains no apparent open reading frame. An accumulation of XIST RNA is observed near its site of transcription, the inactive X chromosome (Xi). A series of molecular cytogenetic studies comparing properties of XIST RNA to other protein coding RNAs, support a critical distinction for XIST RNA; XIST does not concentrate at Xi simply because it is transcribed and processed there. Most notably, morphometric and 3-D analysis… CONTINUE READING

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