XIPOU 2, a noggin-inducible gene, has direct neuralizing activity.

@article{Witta1995XIPOU2A,
  title={XIPOU 2, a noggin-inducible gene, has direct neuralizing activity.},
  author={Samir E Witta and V R Agarwal and Sheryl M Sato},
  journal={Development},
  year={1995},
  volume={121 3},
  pages={721-30}
}
XIPOU 2, a member of the class III POU domain family, is expressed initially in Spemann's organizer, and later, in discrete regions of the developing nervous system in Xenopus laevis. XIPOU 2 may act downstream from initial neural induction events, since it is activated by the neural inducer, noggin. To determine if XIPOU 2 participates in the early events of neurogenesis, synthetic mRNA was microinjected into specific blastomeres of the 32-cell stage embryo. Misexpression of XIPOU 2 in the… CONTINUE READING