XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.

@article{Ramp2004XIAPEI,
  title={XIAP expression is an independent prognostic marker in clear-cell renal carcinomas.},
  author={Uwe Ramp and Thomas Krieg and Ercan Calişkan and Csaba Mahotka and Thomas Ebert and Reinhardt Willers and Helmut Erich Gabbert and Claus Dieter Gerharz},
  journal={Human pathology},
  year={2004},
  volume={35 8},
  pages={1022-8}
}
Deregulation of apoptosis plays an important role in carcinogenesis, tumor progression, and resistance to chemotherapy. XIAP is considered to be the most potent caspase inhibitor of all known IAP (inhibitor of apoptosis) family members. To explore the relevance of XIAP for progression and prognosis in renal cell carcinomas (RCCs) of the clear-cell type, we analyzed XIAP protein expression in formalin-fixed tissue from 145 clear-cell RCCs by immunohistochemistry. XIAP protein expression was… CONTINUE READING

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