XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer

@article{Cao2004XIAPAS,
  title={XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer},
  author={Carolyn Cao and Yi Mu and Dennis E. Hallahan and Bo Lu},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={7047-7052}
}
Survivin and XIAP are members of inhibitors of apoptosis (IAPs) family. They are upregulated in various malignancies. Inactivation of these molecules has resulted in chemosensitization. The purpose of this study was to determine whether inhibition of survivin, XIAP, or both enhances radiotherapy in a lung cancer model. Transient transfection of H460 cells with antisense oligonucleotides (ASOs) against either molecule has specifically reduced their expression, by Western analysis. Results from 3… CONTINUE READING

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